abstract：:To investigate whether the reverse mode of sodium/calcium exchanger subtype 1 (NCX1) plays an important role in the excitability of detrusor cells in rats with partial bladder outflow obstruction (PBOO), PBOO was maintained for 6 weeks in forty female Wistar rats. Thirty of the animals exhibited non-voiding bladder co...

journal_title：American journal of translational research

authors： Zhong X,You N,Wang Q,Li L,Huang C

更新日期：2018-03-15 00:00:00

abstract：:This study reports a case of a 4-year-old boy patient with abnormalities of muscle tone, movement and motor skills, as well as unstable gait leading to frequent falls. The results of the electroencephalogram (EEG) indicate moderately abnormal EEG, accompanied by irregular seizures. Based on these clinical characterist...

journal_title：American journal of translational research

authors： Dong H,Li G,Shang C,Yin H,Luo Y,Meng H,Li X,Wang Y,Lin L,Zhao M

更新日期：2018-03-15 00:00:00

abstract：AIM:This study aimed to investigate the protective effects of paeoniflorin (PAE) on radiation-induced hepatic fibrosis in a rat model. METHODS:Fifty healthy male Sprague-Dawley rats were randomly assigned to normal control group, hepatic fibrosis group, and PAE treatment groups. X-ray exposure was employed to establis...

journal_title：American journal of translational research

authors： Hu Z,Qin F,Gao S,Zhen Y,Huang D,Dong L

更新日期：2018-03-15 00:00:00

abstract：:Mast cells are important effector cells of the immune system, and mast cell-derived exosomes carrying RNAs play a role in immune regulation. However, the molecular function of mast cell-derived exosomes is currently unknown, and here, we identify differentially expressed genes (DEGs) in mast cells and exosomes. We iso...

journal_title：American journal of translational research

authors： Liang Y,Qiao L,Peng X,Cui Z,Yin Y,Liao H,Jiang M,Li L

更新日期：2018-02-15 00:00:00

abstract：:Ulcerative colitis (UC) is a chronic and nonspecific intestinal inflammatory disease, which may increase the risk of colon cancer. Andrographolide is a main active component of Andrographis paniculata. The anti-inflammatory ability of andrographolide suggested its potential therapeutic effect against UC. In the presen...

journal_title：American journal of translational research

authors： Zhu Q,Zheng P,Chen X,Zhou F,He Q,Yang Y

更新日期：2018-02-15 00:00:00

abstract：:A keloid is the process of skin healing, collagen synthesis and metabolism of the loss of normal control in a sustained hyperactive state, resulting in excessive proliferation of collagen fibers. A large-scale genome-wide association study (GWAS) has identified multiple single nucleotide polymorphisms (SNPs) in the 3q...

journal_title：American journal of translational research

authors： Lu MZ,Ang QQ,Zhang X,Zhang LF,Yao XH,Lv H,Zheng XD,Lu WS

更新日期：2018-02-15 00:00:00

abstract：OBJECTIVES:Whether polycystic ovary syndrome (PCOS) is associated with mtDNA or nDNA mutations causing mitochondrial disorders (MIDs) or not is under debate. This review aims at summarising and discussing previous and recent findings concerning the frequency, diagnosis, and treatment of PCOS in MIDs. METHODS:Systemati...

journal_title：American journal of translational research

authors： Finsterer J,Zarrouk-Mahjoub S

更新日期：2018-01-15 00:00:00

abstract：:Long noncoding RNA plasmacytoma variant translocation 1 (PVT1) plays pivotal roles in tumorigenesis of many cancers, including colorectal cancer (CRC). However, the clinical significance and the biological functions of PVT1 in CRC remain largely unknown. In this study, we found that PVT1 was highly expressed in CRC ti...

journal_title：American journal of translational research

authors： Ping G,Xiong W,Zhang L,Li Y,Zhang Y,Zhao Y

更新日期：2018-01-15 00:00:00

abstract：:Development of resistance to doxorubicin-based chemotherapy limits curative effect in breast cancer (BC). N-acetyltransferase 10 (NAT10), a nucleolar protein involved in histone acetylation, is overexpressed in several cancers. We investigated whether NAT10 is involved in doxorubicin resistance in BC and explored the ...

journal_title：American journal of translational research

authors： Wu J,Zhu H,Wu J,Chen W,Guan X

更新日期：2018-01-15 00:00:00

abstract：OBJECTIVE:RAGE pathway plays crucial effects in causing acute lung injury (ALI). Dexmedetomidine (DEX) is showed to mitigate sepsis-stimulated ALI. However, its mechanisms have not been verified. The study was to evaluate whether the RAGE pathway participated in the actions of DEX on sepsis-stimulated ALI in rats. MET...

journal_title：American journal of translational research

authors： Hu H,Shi D,Hu C,Yuan X,Zhang J,Sun H

更新日期：2017-12-15 00:00:00

abstract：:Telocytes are novel cells that have been documented in the interstitium of multiple organs; however, their role in the heart remains unclear. This study aimed to identify cardiac telocytes by their morphological and molecular features and investigate whether their exosomes affect cardiac endothelial cells. To this end...

journal_title：American journal of translational research

authors： Yang J,Li Y,Xue F,Liu W,Zhang S

更新日期：2017-12-15 00:00:00

abstract：:Progression of abdominal aortic aneurysm (AAA) is typified by chronic inflammation and extracellular matrix (ECM) degradation of the aortic wall. Vascular inflammation involves complex interactions among inflammatory cells, endothelial cells (ECs), vascular smooth muscle cells (vSMCs), and ECM. Although vascular endot...

journal_title：American journal of translational research

authors： Ramella M,Boccafoschi F,Bellofatto K,Follenzi A,Fusaro L,Boldorini R,Casella F,Porta C,Settembrini P,Cannas M

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:To further explore the role of PPARγ in QL treatment, ISO-induced mice model and following methods were established. METHODS:Cardiac remodeling on mice model was induced by isoproterenol (ISO) infusion or saline infusion as control for two weeks then divided into 4 groups, after that divided in 5 different ...

journal_title：American journal of translational research

authors： Zhang J,Huang M,Shen S,Wu X,Wu X,Lv P,Zhang H,Wang H,Li X

更新日期：2017-12-15 00:00:00

abstract：:Fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary flavonoid and has been indicated as a novel anti-cancer agent in several types of cancer cells. However, the mechanisms underlying the effect of fisetin in human oral squamous cell carcinoma (OSCC) remain unclear. Here, we report that fisetin significantly inhibits ...

journal_title：American journal of translational research

authors： Li YS,Qin XJ,Dai W

更新日期：2017-12-15 00:00:00

abstract：:Acuteliver failure (ALF) has a high mortality rate and is characterized by massive hepatocyte destruction. Although microRNAs (miRNAs) play an important role in manyliver diseases, the role of miRNAs in ALF development is unknown. In this study, the murine ALF model was induced by intraperitoneal injection of D-galact...

journal_title：American journal of translational research

authors： Feng Z,Li Z,Zhu D,Ling W,Zheng L,Pu L,Kong L

更新日期：2017-11-15 00:00:00

abstract：:Staphylococcus aureus (S. aureus) peptidoglycan (PGN-sa), the major cell wall component of S. aureus, has been demonstrated to be an important virulence factor in the pathogenesis of S. aureus-induced osteomyelitis. However, the exact role of PGN-sa in osteoclastogenesis during S. aureus-induced osteomyelitis and its ...

journal_title：American journal of translational research

authors： Cao F,Zhou W,Liu G,Xia T,Liu M,Mi B,Liu Y

更新日期：2017-11-15 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is an autoimmune disease due to progressive injury of islet cells mediated by T lymphocytes (T cells). Our previous studies have shown that only cathepsin G (CatG), not other proteases, is involved in the antigen presentation of proinsulin, and if the presentation is inhibited, the acti...

journal_title：American journal of translational research

authors： Zou F,Lai X,Li J,Lei S,Hu L

更新日期：2017-11-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most malignant and aggressive brain tumors with great amount of hyaluronan (HA) secretion and CD44 overexpression (HA receptor). CD44 has been suggested as a cancer stem cells (CSCs) marker. However, several clinical studies have indicated that CD44low glioma cell exhibit CS...

journal_title：American journal of translational research

authors： Wang HH,Liao CC,Chow NH,Huang LL,Chuang JI,Wei KC,Shin JW

更新日期：2017-11-15 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ), considered as an ROS scavenger,could protect mitochondrial activity from damage of oxidative stress. To determine the role of PQQ supplement in rescuing long bone osteoporosis in Bmi-1-/- mice. We fed Bmi-1 knockout mice a diet supplemented with PQQ (BKO+PQQ), BKO mice with normal diet ...

journal_title：American journal of translational research

authors： Huang Y,Chen N,Miao D

更新日期：2017-10-15 00:00:00

abstract：:The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were ...

journal_title：American journal of translational research

authors： Nakamura M,Shibata S,Yamasaki T,Ueno M,Nakanishi I,Matsumoto KI,Kamada T,Yamada KI,Aoki I

更新日期：2017-10-15 00:00:00

abstract：:This study tested the hypothesis that combination therapy using extracorporeal shock wave (ECSW)-melatonin (Mel) was superior to either alone at ameliorating neuropathic pain (NP). NP was induced by chronic constriction injury (CCI) to the left sciatic nerve in rats. Animals were categorized into sham control (group 1...

journal_title：American journal of translational research

authors： Chen KH,Yang CH,Wallace CG,Lin CR,Liu CK,Yin TC,Huang TH,Chen YL,Sun CK,Yip HK

更新日期：2017-10-15 00:00:00

abstract：:Lung adenocarcinoma is the most common type of lung cancer. Unfortunately, lung adenocarcinoma has a poor prognosis and the pathogenesis remains unclear. Mitochondria are important mediators of tumorigenesis. However, the proteomics profile of lung adenocarcinoma mitochondrial proteins has not been elucidated. In this...

journal_title：American journal of translational research

authors： Li W,Zhang X,Wang W,Sun R,Liu B,Ma Y,Zhang W,Ma L,Jin Y,Yang S

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Cisplatin is a common used anti-tumor drug in ovarian cancer therapy with potent effect. Studies have reported that autophagy works as a cell-survival process in cancer, chloroquine has been added to various chemotherapeutic drugs. In the current study, we aim to evaluate whether chloroquine can enhance the ...

journal_title：American journal of translational research

authors： Zhu J,Zheng Y,Zhang H,Zhu J,Sun H

更新日期：2017-09-15 00:00:00

abstract：:Random pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery, but the distal part of skin flaps often suffers necrosis due to ischemia. Astragaloside IV (AS-IV), a natural saponin purified from Astragalus membranaceus, may have beneficial functions for flap survival. In this stu...

journal_title：American journal of translational research

authors： Lin R,Chen H,Callow D,Li S,Wang L,Li S,Chen L,Ding J,Gao W,Xu H,Kong J,Zhou K

更新日期：2017-09-15 00:00:00

abstract：:We investigated the protective effects exerted by oridonin, the main active constituent of the Chinese medicinal herb Rabdosiarubescens, against lipopolysaccharide (LPS)/D-galactosamine (D-Gal)-induced acute liver injury (ALI). An ALI model was induced in mice using LPS (40 μg/0.5 ml) and D-Gal (5 mg/0.5 ml). The mice...

journal_title：American journal of translational research

authors： Deng Y,Chen C,Yu H,Diao H,Shi C,Wang Y,Li G,Shi M

更新日期：2017-09-15 00:00:00

abstract：:Incidence of nasopharyngeal carcinoma (NPC) has remained high worldwide, posing a serious health problem. MicroRNAs (miRNAs) are a family of about 20-23 nucleotides small non-coding molecules, which play a significant role in NPC. In this study, we explored the molecular mechanisms of miR-130a-3p in inhibiting viabili...

journal_title：American journal of translational research

authors： Qu R,Sun Y,Li Y,Hu C,Shi G,Tang Y,Guo D

更新日期：2017-08-15 00:00:00

abstract：:Neural stem cells are able to self-renew and generate glial and neuronal lineages. Neural stem cell may serve as therapeutic method for neurological disorders including spinal cord injuries, Parkinson's disease, Huntington's disease and Alzheimer's disease. Long noncoding RNAs (lncRNAs) are longer than 200 nucleotides...

journal_title：American journal of translational research

authors： Zheng J,Yi D,Liu Y,Wang M,Zhu Y,Shi H

更新日期：2017-08-15 00:00:00

abstract：:Lupus nephritis (LN) is a kidney disorder resulting from systemic lupus erythematosus (SLE), an autoimmune inflammatory disease. MicroRNAs (miRNAs) have emerged as a new class of therapeutic targets in LN treatment, but how they specifically contribute to the disease development remains unknown. In this study, the exp...

journal_title：American journal of translational research

authors： Wang W,Gao J,Wang F

更新日期：2017-08-15 00:00:00

abstract：:The aim of the present study was to investigate the effect of modified heterogeneous deproteinized bone combined with bone marrow mesenchymal stem cells (BMSCs) in the restoration of a validated bone defect model. BMSCs were identified by flow cytometry and multilineage differentiation assay. The structural features o...

journal_title：American journal of translational research

authors： Li J,Huang Z,Chen L,Tang X,Fang Y,Liu L

更新日期：2017-07-15 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) act critical roles in many biological processes, including cell proliferation, apoptosis, development, invasion and migration. LncRNA maternally expressed gene 3 (MEG3) is found to be downregulated in several tumors; however, its role in the atherosclerosis is still unknown. In the prese...

journal_title：American journal of translational research

authors： Wu Z,He Y,Li D,Fang X,Shang T,Zhang H,Zheng X

更新日期：2017-07-15 00:00:00

abstract：:MicroRNA-145 (miR-145) can regulate tumor cell invasion, metastasis, apoptosis, proliferation and stem cell differentiation. However, the molecular mechanisms of miR-145 used to regulate ovarian invasion and metastasis remain to be determined. In this study, Transwell cell migration and wound healing assays were used ...

journal_title：American journal of translational research

authors： Wang L,Wu X,Wang B,Wang Q,Han L

更新日期：2017-07-15 00:00:00

abstract：:Biceps tendinopathy is a relatively common ailment that typically presents as pain, tenderness, and weakness in the tendon of the long head of the biceps brachii. Though it is often associated with degenerative processes of the rotator cuff and the joint, this is not always the case, thus, the etiology remains conside...

journal_title：American journal of translational research

authors： Raney EB,Thankam FG,Dilisio MF,Agrawal DK

更新日期：2017-06-15 00:00:00

abstract：:The aim of this study was to evaluate the effects of miR-1180 on pancreatic cancer. We sampled adjacent cancer and carcinoma tissues from 30 pancreatic cancer patients and measured miR-1180 expression by qRT-PCR and NF-κB protein expression by immunohistochemistry. To explore the effects of this miRNA in cell culture,...

journal_title：American journal of translational research

authors： Gu L,Zhang J,Shi M,Peng C

更新日期：2017-06-15 00:00:00

abstract：:WNT1-inducible signaling pathway protein-1 (WISP-1) is an extracellular matrix-related protein that plays multiple roles in cellular physiology and pathology. Accumulating evidence shows that WISP-1 is involved in the process underlying fibrotic diseases. However, the correlation between WISP-1 and renal fibrosis is u...

journal_title：American journal of translational research

authors： Zhong X,Tu YJ,Li Y,Zhang P,Wang W,Chen SS,Li L,Chung AC,Lan HY,Chen HY,Li GS,Wang L

更新日期：2017-06-15 00:00:00

abstract：:Krüppel-like factors (KLFs), such as KLF4, KLF2, KLF5 and KLF15, have been extensively investigated in multi-cancers. However, KLF16, a member of KLFs, hasn't been well identified in cancer, especially in gastric cancer (GC). Here, we investigated the roles of KLF16 in GC. In present study, we found that KLF16 express...

journal_title：American journal of translational research

authors： Ma P,Sun CQ,Wang YF,Pan YT,Chen QN,Liu WT,Liu J,Zhao CH,Shu YQ,Li W

更新日期：2017-06-15 00:00:00

abstract：:Obesity is a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks. One of the alternatives in the treatment of obesity is the traditional use of medicinal plants, which supports the research and development of obesity phytothe...

journal_title：American journal of translational research

authors： de Freitas Junior LM,de Almeida EB Jr

更新日期：2017-05-15 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been recently reported to be dysregulated and play a critical role in the progression of thyroid cancer. Here, we found that the lncRNA n340790 was highly expressed in human thyroid cancer tissues and was strongly correlated with the clinical characteristics of patients. There was a...

journal_title：American journal of translational research

authors： Li Q,Shen W,Li X,Zhang L,Jin X

更新日期：2017-05-15 00:00:00

abstract：:Recent studies have indicated that ATRA inhibits chondrogenesis and can lead to congenital clubfoot (CCF). The molecular mechanism of ATRA-induced chondrogenesis is not clear. As RhoA/ROCK and SDF-1/CXCR4 signaling play important molecular roles for a variety of cellular processes, we hypothesized that RhoA/ROCK2 and ...

journal_title：American journal of translational research

authors： Hu QX,Li XD,Xie P,Wu CC,Zheng GZ,Lin FX,Xie D,Zhang QH,Liu DZ,Wang YG,Chang B,Du SX

更新日期：2017-05-15 00:00:00

abstract：:Macrophages are a major component of tumor stroma and the infiltrated macrophages in malignant tumor tissues (as called tumor associated macrophages, TAM) play a pivotal role in hepatocellular carcinoma (HCC) progression. However, the molecular mechanisms of macrophages promoting HCC metastasis are poorly understood. ...

journal_title：American journal of translational research

authors： Yin Z,Huang J,Ma T,Li D,Wu Z,Hou B,Jian Z

更新日期：2017-05-15 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase which utilizes collagen as a ligand to regulate the interaction between cancer cells and tumor stroma. However, the clinical relevance of DDR1 expression in bladder cancer as well as its molecular regulation have not been previously investigated. Here, w...

journal_title：American journal of translational research

authors： Xie X,Rui W,He W,Shao Y,Sun F,Zhou W,Wu Y,Zhu Y

更新日期：2017-05-15 00:00:00